Hydrochloric Acid → HCID 21249173, compound

HRID 1194675Notes

Reaction equation

HRID 1194675 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([C:14](=O)[CH:15]([CH3:20])[CH2:16][C:17](O)=[O:18])=[CH:10][CH:9]=2)[CH:2]=1.O.[NH2:23][NH2:24].[ClH:25]>COCCO>[ClH:25].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH:15]([CH3:20])[CH2:16][C:17](=[O:18])[NH:23][N:24]=3)=[CH:10][CH:9]=2)[CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 21249125HCID 21249125, compound

Product 1

HCID 21249173HCID 21249173, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

7.1 g (0.025 mole) of 4-(4-(3-pyridylmethyl)-phenyl)-4-oxo-3-methyl-butyric acid and 1.5 ml (0.03 mole) of hydrazine hydrate are stirred in 30 ml of ethylene glycol monomethyl ether at 100° C. for 1 hour. After addition of ethanolic hydrochloric acid, the product is filtered off with suction and recrystallised from 96% strength ethanol.

Workup

  1. filtrationthe product is filtered off with suction
  2. customrecrystallised from 96% strength ethanol

Sources & evidence

ORD record
ord-8c7cf0a6d30b4dd388505b6cb9464c58
Source dataset
uspto-grants-1989_03
Patent number
US04816454

Reaction notes

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