Isopropanol → HCID 21249242, compound

HRID 1194679Notes

Reaction equation

HRID 1194679 reaction equation
Cl.[CH3:2][C:3]1[C:7]2[CH:8]=[C:9]([NH2:13])[CH:10]=[C:11]([F:12])[C:6]=2[S:5][CH:4]=1.[N:14]([O-])=O.[Na+].O.O.[Cl:20][Sn]Cl.C(O)(C)C>O.Cl>[ClH:20].[CH3:2][C:3]1[C:7]2[CH:8]=[C:9]([NH:13][NH2:14])[CH:10]=[C:11]([F:12])[C:6]=2[S:5][CH:4]=1

Participants

7

Reactant 4

HCID 3776IsopropanolHCID 61436Stannous chloride dihydrateHCID 21249246HCID 21249246, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 21249242HCID 21249242, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolvent2×HCID 962WaterSolvent2×

Procedure

0.1 mole of 3-methyl-7-fluoro-5-aminobenzothiophene hydrochloride is suspended in 100 ml of water and 100 ml of concentrated hydrochloric acid, and a solution of 0.11 mole of sodium nitrite in 50 ml of water is added dropwise at between -5° C. and 0° C. The diazonium salt solution is added dropwise to a mixture, cooled to 0° C., of 0.21 mole of SnCl2.2H2O and 200 ml of concentrated hydrochloric acid. After the mixture has been warmed to room temperature, 60 ml of isopropanol are added and the crystal mass is filtered off with suction and recrystallised from isopropanol.

Workup

  1. filtrationthe crystal mass is filtered off with suction
  2. customrecrystallised from isopropanol

Sources & evidence

ORD record
ord-1fe6357c6b2447b68dcb271fd301ab41
Source dataset
uspto-grants-1989_03
Patent number
US04816461

Reaction notes

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