Hydrochloric Acid → HCID 70413842, compound

HRID 1194779Notes

Reaction equation

HRID 1194779 reaction equation
[ClH:1].[CH2:2]([NH:5][CH:6]1[CH2:11][S:10][C:9]2[S:12][CH:13]=[CH:14][C:8]=2[CH2:7]1)[CH2:3][CH3:4].C(=O)([O-])[O-].[Na+].[Na+].[CH2:21](I)[CH2:22][CH2:23][CH3:24].Cl>O.C1(C)C=CC=CC=1>[ClH:1].[CH2:21]([N:5]([CH2:2][CH2:3][CH3:4])[CH:6]1[CH2:11][S:10][C:9]2[S:12][CH:13]=[CH:14][C:8]=2[CH2:7]1)[CH2:22][CH2:23][CH3:24]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 10962Butyl iodideHCID 21268836HCID 21268836, compound

Product 1

HCID 70413842HCID 70413842, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1140TolueneSolvent

Procedure

A mixture of 2,5 g of N-propyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-5-amine hydrochloride, 7.5 g of sodium carbonate, 11 ml of n-butyl iodide 25 ml of toluene and 25 ml of water is refluxed for 3 days. Removal of solvent from the organic layer affords an oil which is treated with ethanolic hydrochloric acid to afford N-butyl- N-propyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-5-amine hydrochloride, m.p. 161°-164°.

Workup

  1. temperatureis refluxed for 3 days
  2. customRemoval of solvent from the organic layer
  3. customaffords an oil which

Sources & evidence

ORD record
ord-625150c96fd540e6a7bf908f01f6ff5f
Source dataset
uspto-grants-1989_03
Patent number
US04816474

Reaction notes

Loading…