反应详情

83.8 g of ethyl 2-(2-amino-4-thiazolyl)-2-(Z)-hydroxyimino-acetate, 94.4 g of N-chloroacetylpiperidine, 202.5 ml of N-ethyldiisopropylamine and 87.6 g of sodium iodide are stirred at room temperature for 12 hours in 1420 ml of acetonitrile. The mixture is diluted with 7 l of ethyl acetate, washed with water, dried over magnesium sulphate and concentrated to a small volume. The substance which crystallizes ot is filtered off and dried. There are obtained 77.2 g of ethyl 2-(2-amino-4-thiazolyl)-2-[(Z)-[(1-piperidinecarbonyl)methoxy]imino]-acetate of melting point 151°-152° C.

1. washwashed with water
2. dry with materialdried over magnesium sulphate
3. concentrationconcentrated to a small volume
4. customThe substance which crystallizes ot
5. filtrationis filtered off
6. customdried