反应详情

99 g of ethyl 2-(2-amino-4-thiazolyl)-2-(Z)-hydroxyimino-acetate, 121.4 g of N-chloroacetylhexamethyleneimine, 238 ml of N-ethyldiisopropylamine and 103.5 g of sodium iodide are stirred at room temperature for 12 hours in 1675 ml of acetonitrile. The mixture is poured into 7 l of ethyl acetate, washed with water, dried over magnesium sulphate and concentrated. After recrystallization from isopropyl acetate, there are obtained 136 g of ethyl 2-(2-amino-4-thiazolyl)-2-[(Z)-[[(hexahydro-1H-azepin-1-yl)carbonyl]methoxy]imino]-acetate of melting point 163°-164° C.

1. washwashed with water
2. dry with materialdried over magnesium sulphate
3. concentrationconcentrated
4. customAfter recrystallization from isopropyl acetate, there