反应详情

17.7 g of ethyl 2-(2-amino-4-thiazolyl)-2-(Z)-hydroxyimino-acetate are suspended in 320 ml of acetonitrile, treated successively with 27.6 ml of N-ethyldiisopropylamine, 16 g of 5-chloromethyl-1-methyl-tetrazole and 24 g of sodium iodide and the mixture is stirred at room temperature for 12 hours. The mixture is subsequently diluted with 1.5 l of ethyl acetate, washed three times with 500 ml of water each time, dried over magnesium sulphate and concentrated. There are obtained 39.6 g of ethyl 2-(2-amino-4-thiazolyl)-2-[(Z)-[(1-methyl-1H-tetrazol-5-yl)methoxy]imino]-acetate as an oil which is used directly.

1. washwashed three times with 500 ml of water each time
2. dry with materialdried over magnesium sulphate
3. concentrationconcentrated