1,2-Dichloroethane → HCID 19819138, compound

HRID 1195452Notes

Reaction equation

HRID 1195452 reaction equation
Cl[CH2:2][CH2:3][C:4](Cl)=[O:5].[Cl-:7].[Al+3].[Cl-].[Cl-].C[C:12]1[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=1.Cl.[CH2:20](Cl)CCl>>[Cl:7][CH:3]([CH3:2])[C:4]([C:15]1([CH3:18])[CH:16]=[C:17]([CH3:20])[CH:12]=[CH:13][CH2:14]1)=[O:5]

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 7809P-XyleneHCID 693643-Chloropropionyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 19819138HCID 19819138, compound

Procedure

β-Chloropropionyl chloride (71.9 g, 566 mmole) was added to a mixture of aluminium chloride (75.5 g, 566 mmole) and ethylene dichloride (200 ml). To this mixture was added p-xylene (60.0 g, 566 mmole) and the solution was stirred at room temperature for 30 minutes, then poured into dilute hydrochloric acid. The organic layer was separated, washed with water and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gave 2-(2-chloropropionyl)-2,4-dimethylbenzene a yellowish oil, which was used immediately in the next step of the sequence.

Workup

  1. customThe organic layer was separated
  2. washwashed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customEvaporation of the solvent under reduced pressure

Sources & evidence

ORD record
ord-a11b6f9c40d34200b5b493543209aba2
Source dataset
uspto-grants-1992_05
Patent number
US05110989

Reaction notes

Loading…