Sodium Iodide → HCID 19807720, compound

HRID 1195591Notes

Reaction equation

HRID 1195591 reaction equation
Cl[CH2:2][C:3]1[CH2:4][O:5][CH2:6][CH2:7][CH:8]=1.[Cl:9][C:10]1[N:11]([C:19]2[CH:24]=[C:23]([OH:25])[C:22]([Cl:26])=[CH:21][C:20]=2[F:27])[N:12]=[C:13]2[C:18]=1[CH2:17][CH2:16][CH2:15][CH2:14]2.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CN(C)C=O.O>[Cl:9][C:10]1[N:11]([C:19]2[CH:24]=[C:23]([O:25][CH2:2][C:3]3[CH2:4][O:5][CH2:6][CH2:7][CH:8]=3)[C:22]([Cl:26])=[CH:21][C:20]=2[F:27])[N:12]=[C:13]2[C:18]=1[CH2:17][CH2:16][CH2:15][CH2:14]2

Participants

7

Reactant 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 1850782-Chloro-5-(3-chloro-4,5,6,7-tetrahydroindazol-2-yl)-4-fluorophenolHCID 198077223-(Chloromethyl)-5,6-dihydro-2H-pyran

Product 1

HCID 19807720HCID 19807720, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

2.1 g (16 mmol) of 3-chloromethyl-5,6-dihydro-2H-pyran were added at 25° C. to a mixture of 4.5 g (15 mmol) of 3-chloro-2-(4-chloro-2-flouro-5-hydroxyphenyl)-4,5,6,7-tetrahydroindazole, 2.5 g (18 mmol) of potassium carbonate and 0.5 g (3mmol) of sodium iodide in 50 ml of dimethylformamide, and the reaction mixture was stirred for 12 hours. 100 ml of water were added, and the precipitate was isolated, washed with water and dried, resulting in 5 g (84%) of the title compound [melting point 90° to 92° C⟧ Compound No. 1.002.

Workup

  1. customthe precipitate was isolated
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-51c2b0b3e4f04db2840683ae2366245f
Source dataset
uspto-grants-1992_05
Patent number
US05112383

Reaction notes

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