Phosphorus oxychloride → HCID 14857385, compound

HRID 1195814Notes

Reaction equation

HRID 1195814 reaction equation
[CH3:1][C:2]1([CH3:22])[CH2:11][CH:10]([C:12]2[C:13](=[O:18])[NH:14][CH:15]=[CH:16][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:19](=O)[NH2:20])[CH:8]=2)[O:3]1.O=P(Cl)(Cl)Cl>ClCCCl>[CH3:1][C:2]1([CH3:22])[CH2:11][CH:10]([C:12]2[C:13](=[O:18])[NH:14][CH:15]=[CH:16][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:19]#[N:20])[CH:8]=2)[O:3]1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 14857381HCID 14857381, compound

Product 1

HCID 14857385HCID 14857385, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

A mixture of 2.98 g of 2,2-dimethyl-4-(1,2-dihydro-2-oxo-3-pyridyl)-6-carbamoylchroman,2 ml of POCl3 and 200 ml of 1,2-dichloroethane is boiled for 45 min. Cooling and customary working up gives 2,2-dimethyl-4-(1,2-dihydro-2-oxo-3-pyridyl)-6-cyanochroman, m.p. 174°-175.5°.

Workup

  1. temperatureCooling

Sources & evidence

ORD record
ord-e8ef9b70feeb4a3aba38700d4231d5f8
Source dataset
uspto-grants-1992_05
Patent number
US05112839

Reaction notes

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