Hydrochloric Acid → HCID 67831434, compound

HRID 1196153Notes

Reaction equation

HRID 1196153 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl.[P:14](=[O:18])([OH:17])([OH:16])[OH:15].[CH3:19]O>>[P:14]([OH:18])([OH:17])([OH:16])=[O:15].[CH3:19][O:11][C:10](=[O:12])[C@H:2]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[NH2:1]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1004Phosphoric AcidHCID 6140L-Phenylalanine

Product 1

HCID 67831434HCID 67831434, compoundYield 61.1%

Procedure

The same esterification procedure as in Example 1 was followed with the exception that 165.2 g of L-phenylalanine and 165.2 g of methanol were used and that hydrochloric acid was replaced with 132.1 g of 89% phosphoric acid. The reaction was conducted at 60 ° C. for 8 hours, followed by cooling in order to deposit the crystals, which were collected by filtration and then dried to obtain 169.4 g (58.1% yield) of L-phenylalanine methyl ester phosphate having a purity of 95.1% and containing 0.3% of water and 3.0% of L-phenylalanine.

Workup

  1. temperatureby cooling in order
  2. filtrationwere collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-b3893158eefe43a6ada5debf31ca0114
Source dataset
uspto-grants-1992_05
Patent number
US05113009

Reaction notes

Loading…