HCID 19938212, compound → N-methylcyclohexanecarboxamide

HRID 1196165Notes

Reaction equation

HRID 1196165 reaction equation
COCOC1C=CC(C(C2C=CC(OCOC)=CC=2)C2C=CC=C[C:13]=2[N:18](C)[C:19]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[O:20])=CC=1>C(OCC)(=O)C.Cl>[CH3:13][NH:18][C:19]([CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)=[O:20]

Participants

4

Reactant 1

HCID 19938212HCID 19938212, compound

Product 1

HCID 3343827N-methylcyclohexanecarboxamideYield 50.7%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

In 50 ml of ethyl acetate saturated with hydrogen chloride was dissolved 2.18 g of compound 137 obtained by Example 137, and the solution was stirred for 1 hour. Thereafter, the solvent was evaporated under reduced pressure, and the residue was recrystallized from methanol to afford 0.31 g of the desired compound (Compound 138).

Workup

  1. customThereafter, the solvent was evaporated under reduced pressure
  2. customthe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-3d788a5b39fd4ffba4fd3e042f0e2bd2
Source dataset
uspto-grants-1992_05
Patent number
US05112867

Reaction notes

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