Triphenylphosphine → HCID 19898753, compound

HRID 1196725Notes

Reaction equation

HRID 1196725 reaction equation
C(N(CCO)CCNC1N(C)C(=O)N(C)C(=O)C=1)C.C(OC(C1OC2C=C(O)C=CC=2C(=O)C=1)=O)C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O.C([O-])(=O)C([O-])=O.C(O)(=O)C(O)=O.[CH3:80][N:81]1[C:86]([NH:87][CH2:88][CH2:89][N:90]([CH2:110][CH3:111])[CH2:91][CH2:92][O:93][C:94]2[CH:109]=[CH:108][C:97]3[C:98](=[O:107])[CH:99]=[C:100]([C:102]([O:104][CH2:105][CH3:106])=[O:103])[O:101][C:96]=3[CH:95]=2)=[CH:85][C:84](=[O:112])[N:83]([CH3:113])[C:82]1=[O:114]>O1CCCC1>[CH3:80][N:81]1[C:86]([NH:87][CH2:88][CH2:89][N:90]([CH2:110][CH3:111])[CH2:91][CH2:92][O:93][C:94]2[CH:109]=[CH:108][C:97]3[C:98](=[O:107])[CH:99]=[C:100]([C:102]([O:104][CH2:105][CH3:106])=[O:103])[O:101][C:96]=3[CH:95]=2)=[CH:85][C:84](=[O:112])[N:83]([CH3:113])[C:82]1=[O:114]

Participants

8

Reactant 6

HCID 11776TriphenylphosphineHCID 71081OxalateHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 5376802ethyl 7-hydroxy-4-oxo-4H-chromen-2-carboxylate2×HCID 19898752HCID 19898752, compoundHCID 19898770HCID 19898770, compound2×

Product 1

HCID 19898753HCID 19898753, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The same procedure as in Example 8-(2) was effected so as to react and treat 0.6 g of N-ethyl-N-(2-hydroxyethyl)-N'[1,3-dimethyl-2,4-dioxopyrimidine-6-yl]ethylenediamine (Compound 32), 0.57 g of 2-ethoxycarbonyl-7-hydroxy-4-oxo-4H-1-benzopyran (Compound 33), 30 ml of tetrahydrofuran containing 0.77 g of triphenylphosphine and 0.47 ml of diethyl azodicarboxylate, thereby obtaining 0.81 g (yield 69%) of oily 1,3-dimethyl-6-(2-[N-ethyl-N-[2-(2-ethoxycarbonyl-4-oxo-4H-1-benzopyran-7-yl)oxyethyl]amino]ethylamino)-2,4(1H,3H)-pyrimidinedione (the non-oxalate of Compound 34).

Workup

  1. customto react

Sources & evidence

ORD record
ord-835f228946be43fe8ef7303be9daec2e
Source dataset
uspto-grants-1992_05
Patent number
US05114941

Reaction notes

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