反应详情

温度

60 °C

In 2 ml of dimethylformamide were dissolved 190 mg of ethyl 5-hydroxy-1-methoxyindane-2-acetate and 220 mg of p-heptyloxybenzyl chloride. To the solution was added 180 mg of potassium carbonate. The mixture was stirred at 60° C. overnight. After allowing to cool, water and ethyl acetate were added to the mixture. By thoroughly shaking the mixture, the organic layer was separated. After washing with water, drying and concentrating the organic layer, the residue obtained was purified by flash chromatography (eluant: toluene/ethyl acetate (25/1)) to obtain 220 mg of ethyl 5-(p-heptyloxybenzyloxy)-1-methoxy-2-indaneacetate as a colorless oily product.

1. temperatureto cool
2. stirringBy thoroughly shaking the mixture
3. customthe organic layer was separated
4. washAfter washing with water
5. customdrying
6. concentrationconcentrating the organic layer
7. customthe residue obtained
8. customwas purified by flash chromatography (eluant: toluene/ethyl acetate (25/1))