反应详情

Benzyl bromide (1.8 g), 1-furoyl-2-t-butyl hydrazine (2 g) and excess powdered potassium carbonate were stirred in dimethylformamide (50 ml) at 50° C. for 2 hours. The reaction mixture was cooled to room temperature, diluted with diethyl ether and washed several times with water. The organic layer was dried over magnesium sulfate, filtered, and the solvent removed in vacuo. The white solid product was chromatographed on silica gel (G:70°-230 mesh) using methylene chloride as eluent to afford the product in good yield: m.p. 152°-153.

1. washwashed several times with water
2. dry with materialThe organic layer was dried over magnesium sulfate
3. filtrationfiltered
4. customthe solvent removed in vacuo
5. customThe white solid product was chromatographed on silica gel (G:70°-230 mesh)
6. customto afford the product in good yield