Hydrogen Peroxide → HCID 88444043, compound

HRID 1197483Notes

Reaction equation

HRID 1197483 reaction equation
[Cl:1][C:2](=[N:7][NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15][CH2:16][C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[CH2:18])[C:3]([O:5][CH3:6])=[O:4].OO.C(=O)(O)[O-:28].[Na+].S(=O)(O)[O-].[Na+]>C(O)(=O)C.O>[Cl:1][C:2](=[N:7][NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([CH2:16][C:17]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[CH2:18])=[O:28])[C:3]([O:5][CH3:6])=[O:4]

Participants

7

Reactant 4

HCID 784Hydrogen PeroxideHCID 516892Sodium BicarbonateHCID 23665763Sodium BisulfiteHCID 88443983HCID 88443983, compound

Product 1

HCID 88444043HCID 88444043, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

The compound of Step B (5 g) was stirred with occasional warming in acetic acid (45 ml) and treated with 30% aqueous hydrogen peroxide (2.0 ml). After stirring for 5 h, water (200 ml) was added and the P.h. was adjusted to 6 with sodium bicarbonate. Saturated sodium bisulfite solution (3 ml) was added and the mixture was extracted with dichloromethane (200 ml). The organic layer was dried and evaporated to give the title compound (4.9 g).

Workup

  1. extractionthe mixture was extracted with dichloromethane (200 ml)
  2. customThe organic layer was dried
  3. customevaporated

Sources & evidence

ORD record
ord-399598ea41ca45e181d1dc4e0b455d4b
Source dataset
uspto-grants-1994_01
Patent number
US05276039

Reaction notes

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