Ethyl Bromide → HCID 178437662, compound

HRID 1197855Notes

Reaction equation

HRID 1197855 reaction equation
[Mg].Br[CH2:3][CH3:4].[Cl:5][C:6]1[N:11]=[C:10]([Cl:12])[C:9]([F:13])=[CH:8][N:7]=1>O1CCCC1.COCCOC>[Cl:5][C:6]1[NH:7][CH:8]([CH2:3][CH3:4])[C:9]([F:13])=[C:10]([Cl:12])[N:11]=1

Participants

6

Reactant 3

HCID 6332Ethyl BromideHCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 5462224Magnesium

Product 1

HCID 178437662HCID 178437662, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent2×HCID 80711,2-DimethoxyethaneSolvent

Procedure

To magnesium turnings (4.27 g) in tetrahydrofuran (56 ml) was added a solution of bromoethane (19 g) in THF (19 ml) over 5 hours. To this slurry at 0° C. was added a solution of the product of part (i) (24 g) in 1,2-dimethoxyethane (70 ml) over 1 hour. The reaction was quenched at 10° C. using glacial acetic acid (10 g) to give a solution of the title compound which was used directly in the next step.

Workup

  1. customThe reaction was quenched at 10° C.

Sources & evidence

ORD record
ord-d938da8f58d54d6db8b648914a06d807
Source dataset
uspto-grants-1994_01
Patent number
US05278175

Reaction notes

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