p-Toluenesulfonic acid → HCID 54556855, compound

HRID 1198053Notes

Reaction equation

HRID 1198053 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6](=[O:22])[CH2:7][C:8]([OH:21])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:2].C1(C)C=CC(S(O)(=O)=O)=CC=1.[O:35]1[CH:40]=[CH:39][CH2:38][CH2:37][CH2:36]1>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6](=[O:22])[CH2:7][C:8]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)([O:21][CH:36]1[CH2:37][CH2:38][CH2:39][CH2:40][O:35]1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[CH3:2]

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 80803,4-dihydro-2H-pyranHCID 255514ethyl 5-hydroxy-3-oxo-5,5-diphenylpentanoate

Product 1

HCID 54556855HCID 54556855, compound

Procedure

The title compound (J. W. Wolfe, et al, J. Org. Chem. 29, 3249 (1964) ) was prepared from δ-hydroxy-β-oxo-δ-phenylbenzenepentanoic acid ethyl ester (2.0 g, 0.006 mol), p-toluenesulfonic acid (0.014 g, 0.60 mmol), and 3,4-dihydro-2H-pyran (0.77 g, 0.009 mol) using the procedure described in Example 6, Step A.

Sources & evidence

ORD record
ord-d576f722625042c7a04eefde12a66917
Source dataset
uspto-grants-1994_01
Patent number
US05278326

Reaction notes

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