反应详情

35 g of (S)-2-pentanol was dissolved in tetrahydrofuran, and 16 g of 60% sodium hydride was added thereto. After stirring for 30 minutes, 80 g of bromoacetaldehyde diethylacetal was added thereto, and the mixture was refluxed for 6 hours. After the reaction solution was concentrated and water and ether were added thereto, the mixture was shaken for mixing. The organic layer was collected and was dried with magnesium sulfate to remove the solvent off. Purification was carried out by column chromatography to obtain 2-(4-methylbutyloxy)acetaldehyde diethylacetal (54).

1. temperaturethe mixture was refluxed for 6 hours
2. concentrationAfter the reaction solution was concentrated
3. additionwater and ether were added
4. stirringthe mixture was shaken
5. additionfor mixing
6. customThe organic layer was collected
7. dry with materialwas dried with magnesium sulfate
8. customto remove the solvent off
9. customPurification