Hydrochloric Acid → HCID 135703694, compound

HRID 1198726Notes

Reaction equation

O1CCO[CH:2]1[C:6]1[CH:11]=[C:10]([CH3:12])[C:9]([NH:13][OH:14])=[CH:8][N:7]=1.[NH2:15][NH:16][C:17]([NH2:19])=[S:18].Cl.C(=O)(O)[O-].[Na+]>>[OH:14][NH:13][C:9]1[C:10]([CH3:12])=[CH:11][C:6]([CH:2]=[N:15][NH:16][C:17]([NH2:19])=[S:18])=[N:7][CH:8]=1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 516892Sodium Bicarbonate

HCID 2723789Thiosemicarbazide

HCID 10081379HCID 10081379, compound

Product 1

HCID 135703694HCID 135703694, compound

Procedure

Condensation of 2-(1,3-dioxolanyl)-4-methyl-5-hydroxyaminopyridine with thiosemicarbazide in the presence of concentrated hydrochloric acid, followed by treatment with sodium bicarbonate afforded the desired 5-hydroxyamino-4-methyl-2-formylpyridine thiosemicarbazone.

Sources & evidence

ORD record: ord-0f8aff5afa5a4b5e8b14bacb08c1bd21
Source dataset: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05281715

Reaction notes

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