Oxalic acid dihydrate → 4-Methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione

HRID 1199660Notes

Reaction equation

HRID 1199660 reaction equation
[NH2:1][C:2]1[C:3]([NH:8][CH3:9])=[N:4][CH:5]=[CH:6][CH:7]=1.O.O.[C:12](O)(=[O:16])[C:13](O)=[O:14]>Cl>[CH3:9][N:8]1[C:13](=[O:14])[C:12](=[O:16])[NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]1=2

Participants

4

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 123436692-N-methylpyridine-2,3-diamine

Product 1

HCID 131929424-Methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3-amino-2-(N-methylamino)-pyridine (0.1 mol) and oxalic acid dihydrate (0,12 mol) was dissolved in 4N HCl (400 ml). The solution was refluxed for 8 hours and then cooled to room temperature whereby the title compound precipitated as crystals. The crystals were separated by filtration and then washed with water. m.p. 271°-272° C.

Workup

  1. temperatureThe solution was refluxed for 8 hours

Sources & evidence

ORD record
ord-10f3312d2eb84e8bb731121522f952e7
Source dataset
uspto-grants-1990_02
Patent number
US04902686

Reaction notes

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