Dimethylformamide → N-(4-fluorophenyl)-N'-(4-{[2-methyl-6,7-bis(methyloxy)quinazolin-4-yl]oxy}phenyl)cyclopropane-1,1-dicarboxamide

HRID 1200417Notes

Reaction equation

HRID 1200417 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:16][c:17]3[cH:18][cH:19][c:20]([NH2:23])[cH:21][cH:22]3)[n:7][c:8]([CH3:15])[n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14].[CH3:78][CH2:79][O:80][C:81]([CH3:82])=[O:83].[CH:40]([N:41]([CH2:42][CH3:43])[CH:44]([CH3:45])[CH3:46])([CH3:47])[CH3:48].[F:24][c:25]1[cH:26][cH:27][c:28]([NH:31][C:32](=[O:33])[C:34]2([C:37](=[O:38])[OH:39])[CH2:35][CH2:36]2)[cH:29][cH:30]1.[O:73]=[CH:74][N:75]([CH3:76])[CH3:77].[P-:49]([F:50])([F:51])([F:52])([F:53])([F:54])[F:55].[n:56]1([O:57][C:58]([N:59]([CH3:60])[CH3:61])=[N+:62]([CH3:63])[CH3:64])[c:65]2[n:66][cH:67][cH:68][cH:69][c:70]2[n:71][n:72]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:16][c:17]3[cH:18][cH:19][c:20]([NH:23][C:37]([C:34]4([C:32]([NH:31][c:28]5[cH:27][cH:26][c:25]([F:24])[cH:30][cH:29]5)=[O:33])[CH2:35][CH2:36]4)=[O:38])[cH:21][cH:22]3)[n:7][c:8]([CH3:15])[n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14]

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 210815301-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic AcidHCID 578102514-(6,7-Dimethoxy-2-methyl-quinazolin-4-yloxy)-phenylamine

Product 1

HCID 57810414N-(4-fluorophenyl)-N'-(4-{[2-methyl-6,7-bis(methyloxy)quinazolin-4-yl]oxy}phenyl)cyclopropane-1,1-dicarboxamide

Sources & evidence

ORD record
ord-5957adbe64a041fd8f784eccb8e1005d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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