Acetonitrile → 2-Amino-3-cyano-4-methyl-5-(trimethylsilylethynyl)pyridine

HRID 120128Notes

Reaction equation

[CH3:12][Si:13]([CH3:14])([CH3:15])[C:16]#[CH:17].[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[CH3:25][C:26]#[N:27].[Cu:28][I:29].[NH2:1][c:2]1[n:3][cH:4][c:5]([I:11])[c:6]([CH3:10])[c:7]1[C:8]#[N:9]>>[NH2:1][c:2]1[n:3][cH:4][c:5]([C:17]#[C:16][Si:13]([CH3:12])([CH3:14])[CH3:15])[c:6]([CH3:10])[c:7]1[C:8]#[N:9]

Participants

Reactant 5

HCID 6342Acetonitrile

HCID 8471Triethylamine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 66111Trimethylsilylacetylene

HCID 113912652-Amino-5-iodo-4-methylnicotinonitrile

Product 1

HCID 197071982-Amino-3-cyano-4-methyl-5-(trimethylsilylethynyl)pyridine

Sources & evidence

ORD record: ord-43b116c6744945a1a1009b1c6ae717ad
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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