Bromide ion → 2-Chloro-6-propylimidazo[1,2-b]pyridazine

HRID 1202549Notes

Reaction equation

HRID 1202549 reaction equation
[Br-:1].[CH2:2]([CH2:3][CH3:4])[Zn+:5].[CH3:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.[Cl:11][c:12]1[n:13][c:14]2[n:15]([n:16][c:17]([Cl:20])[cH:18][cH:19]2)[cH:21]1.[ClH:22].[O:6]1[CH2:7][CH2:8][CH2:9][CH2:10]1.[OH2:71].[Pd:30]([Cl:31])[Cl:32].[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[cH:47][cH:48][cH:49][cH:50][cH:51]1.[c:52]1([P:53]([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[cH:66][cH:67][cH:68][cH:69][cH:70]1>>[CH2:2]([CH2:3][CH3:4])[c:17]1[n:16][n:15]2[c:14]([n:13][c:12]([Cl:11])[cH:21]2)[cH:19][cH:18]1

Participants

10

Reactant 9

HCID 259Bromide ionHCID 313Hydrochloric AcidHCID 962WaterHCID 1140TolueneHCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 144223582,6-Dichloroimidazo[1,2-b]pyridazineHCID 178455867HCID 178455867, compound

Product 1

HCID 230280952-Chloro-6-propylimidazo[1,2-b]pyridazine

Sources & evidence

ORD record
ord-83cdbca6f36d4c1e9ed0b78f1874f761
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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