Dimethylformamide → Methyl 4-cyano-6-[[3-methoxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]amino]-2-(1-methylpyrazol-4-yl)pyridine-3-carboxylate

HRID 1202612Notes

Reaction equation

HRID 1202612 reaction equation
[CH3:48][CH2:49][O:50][C:51]([CH3:52])=[O:53].[CH:34]([N:35]([CH2:36][CH3:37])[CH:38]([CH3:39])[CH3:40])([CH3:41])[CH3:42].[Cl:1][c:2]1[n:3][c:4](-[c:14]2[cH:15][n:16][n:17]([CH3:19])[cH:18]2)[c:5]([C:6](=[O:7])[O:8][CH3:9])[c:10]([C:12]#[N:13])[cH:11]1.[NH2:20][CH2:21][CH:22]([CH2:23][O:24][CH3:25])[NH:26][C:27]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33].[O:43]=[CH:44][N:45]([CH3:46])[CH3:47]>>[c:2]1([NH:20][CH2:21][CH:22]([CH2:23][O:24][CH3:25])[NH:26][C:27]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33])[n:3][c:4](-[c:14]2[cH:15][n:16][n:17]([CH3:19])[cH:18]2)[c:5]([C:6](=[O:7])[O:8][CH3:9])[c:10]([C:12]#[N:13])[cH:11]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 45092031tert-butyl N-(1-amino-3-methoxypropan-2-yl)carbamateHCID 58317582methyl 6-chloro-4-cyano-2-(1-methyl-1H-pyrazol-4-yl)nicotinate

Product 1

HCID 67238065Methyl 4-cyano-6-[[3-methoxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]amino]-2-(1-methylpyrazol-4-yl)pyridine-3-carboxylate

Sources & evidence

ORD record
ord-aeb9a01c982c4a8f94ab3b05dd6c6fe7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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