1,2-Dichloroethane → N1-(4-(2-(3-(tert-Butyldimethylsilyloxy)azetidine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-methoxyphenyl)malonamide
Reaction equation
[CH2:48]([Cl:49])[CH2:50][Cl:51].[CH3:33][O:34][c:35]1[c:36]([NH:41][C:42]([CH2:43][C:44](=[O:45])[OH:46])=[O:47])[cH:37][cH:38][cH:39][cH:40]1.[CH3:57][CH2:58][O:59][C:60]([CH3:61])=[O:62].[NH2:1][c:2]1[cH:3][c:4]([F:32])[c:5]([O:6][c:7]2[c:8]3[c:9]([n:10][cH:11][cH:12]2)[cH:13][c:14]([C:16](=[O:17])[N:18]2[CH2:19][CH:20]([O:22][Si:23]([CH3:24])([CH3:25])[C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:21]2)[s:15]3)[cH:30][cH:31]1.[O:52]=[CH:53][N:54]([CH3:55])[CH3:56]>>[NH:1]([c:2]1[cH:3][c:4]([F:32])[c:5]([O:6][c:7]2[c:8]3[c:9]([n:10][cH:11][cH:12]2)[cH:13][c:14]([C:16](=[O:17])[N:18]2[CH2:19][CH:20]([O:22][Si:23]([CH3:24])([CH3:25])[C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:21]2)[s:15]3)[cH:30][cH:31]1)[C:44]([CH2:43][C:42]([NH:41][c:36]1[c:35]([O:34][CH3:33])[cH:40][cH:39][cH:38][cH:37]1)=[O:47])=[O:45]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-2ee0f4c24a254048acf25276dc0a59d5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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