Benzyl Bromide → 1-Benzyloxy-7-chloro-6-fluoro-isoquinoline
Reaction equation
[Ag+2:37].[Br:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[C:33](=[O:34])([O-:35])[O-:36].[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:22][CH2:23][O:24][C:25](=[O:26])[CH3:27].[Cl:1][c:2]1[c:3]([F:13])[cH:4][c:5]2[cH:6][cH:7][nH:8][c:9](=[O:12])[c:10]2[cH:11]1>>[Cl:1][c:2]1[c:3]([F:13])[cH:4][c:5]2[cH:6][cH:7][n:8][c:9]([O:12][CH2:15][c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[c:10]2[cH:11]1Participants
7
Sources & evidence
- ORD record
- ord-5d7071e4c26b4523a12b32a50fc3850d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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