Hydrochloric Acid → tert-Butyl 4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

HRID 1207703Notes

Reaction equation

HRID 1207703 reaction equation
[CH3:31][CH2:32][N:33]([CH2:34][CH3:35])[CH2:36][CH3:37].[CH:1]([CH3:2])([CH3:3])[c:4]1[s:5][cH:6][c:7]([C:9](=[O:10])[OH:11])[n:8]1.[ClH:12].[O:13]1[CH2:14][CH2:15][NH:16][CH2:17][C:18]12[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]2.[O:62]=[CH:63][N:64]([CH3:65])[CH3:66].[P-:38]([F:39])([F:40])([F:41])([F:42])([F:43])[F:44].[n:45]1([O:46][C:47]([N:48]([CH3:49])[CH3:50])=[N+:51]([CH3:52])[CH3:53])[c:54]2[n:55][cH:56][cH:57][cH:58][c:59]2[n:60][n:61]1>>[CH:1]([CH3:2])([CH3:3])[c:4]1[s:5][cH:6][c:7]([C:9](=[O:11])[N:16]2[CH2:15][CH2:14][O:13][C:18]3([CH2:17]2)[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]3)[n:8]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 225730652-(Propan-2-yl)-1,3-thiazole-4-carboxylic acidHCID 53302318tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Product 1

HCID 57989200tert-Butyl 4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Sources & evidence

ORD record
ord-47f92b9d6b4844b2bb49a1c864b09e0f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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