Water → Ethyl 3-(2,3-dihydrobenzofuran-5-yl)-2-phenylpropionate

HRID 1208770Notes

Reaction equation

HRID 1208770 reaction equation
[Br:37][CH2:38][c:39]1[cH:40][cH:41][c:42]2[c:43]([cH:47]1)[CH2:44][CH2:45][O:46]2.[CH2:20]([Li:21])[CH2:22][CH2:23][CH3:24].[CH3:11][Si:12]([CH3:13])([CH3:14])[NH:15][Si:16]([CH3:17])([CH3:18])[CH3:19].[CH3:1][Si:2]([CH3:3])([CH3:4])[N-:5][Si:6]([CH3:7])([CH3:8])[CH3:9].[Li+:10].[O:48]1[CH2:49][CH2:50][CH2:51][CH2:52]1.[OH2:53].[c:25]1([CH2:31][C:32](=[O:33])[O:34][CH2:35][CH3:36])[cH:26][cH:27][cH:28][cH:29][cH:30]1>>[c:25]1([CH:31]([C:32](=[O:33])[O:34][CH2:35][CH3:36])[CH2:38][c:39]2[cH:40][cH:41][c:42]3[c:43]([cH:47]2)[CH2:44][CH2:45][O:46]3)[cH:26][cH:27][cH:28][cH:29][cH:30]1

Participants

9

Reactant 8

HCID 962WaterHCID 7590Ethyl phenylacetateHCID 8028TetrahydrofuranHCID 13838HexamethyldisilazaneHCID 28486Lithium ionHCID 3280088Npc316347HCID 220048075-(Bromomethyl)-2,3-dihydrobenzofuranHCID 178418339Butyllithium

Product 1

HCID 22004839Ethyl 3-(2,3-dihydrobenzofuran-5-yl)-2-phenylpropionate

Sources & evidence

ORD record
ord-5f813a90e341492c8258ef7001483afa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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