Formic Acid → Methyl 5-fluoro-6-(pyrrolidin-1-yl)nicotinate
Reaction equation
[CH3:111][CH2:112][O:113][C:114](=[O:115])[CH3:116].[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[CH3:29][N:30]([CH3:31])[CH:32]=[O:33].[CH:25]([OH:26])=[O:27].[Cl:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH3:7])[cH:8][c:9]([F:17])[c:10]([N:12]2[CH2:13][CH2:14][CH2:15][CH2:16]2)[n:11]1.[OH2:28].[cH:34]1[cH:35][cH:36][c:37]([P:38]([Pd:39]([P:40]([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)([c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[P:78]([c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)([c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)[c:91]2[cH:92][cH:93][cH:94][cH:95][cH:96]2)([c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)[c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)[cH:109][cH:110]1>>[cH:2]1[c:3]([C:4](=[O:5])[O:6][CH3:7])[cH:8][c:9]([F:17])[c:10]([N:12]2[CH2:13][CH2:14][CH2:15][CH2:16]2)[n:11]1Participants
8
Sources & evidence
- ORD record
- ord-7f5664d4a88a40a8a2fa67004c623606
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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