Hydrochloric Acid → 4-fluoro-5-[3-fluoro-2-methyl-5-[[1-(1,8-naphthyridin-2-yl)cyclopropyl]carbamoyl]phenyl]-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

HRID 1211615Notes

Reaction equation

HRID 1211615 reaction equation
[CH2:16]([N:17]([CH:18]([CH3:19])[CH3:20])[CH:21]([CH3:22])[CH3:23])[CH3:24].[ClH:15].[F:25][c:26]1[cH:27][c:28]([C:29](=[O:30])[OH:31])[cH:32][c:33](-[c:36]2[cH:37][cH:38][c:39]3[c:40]([c:41]([C:51]([NH:52][CH3:53])=[O:54])[c:42](-[c:44]4[cH:45][cH:46][c:47]([F:50])[cH:48][cH:49]4)[o:43]3)[c:55]2[F:56])[c:34]1[CH3:35].[O:81]=[CH:82][N:83]([CH3:84])[CH3:85].[P-:57]([F:58])([F:59])([F:60])([F:61])([F:62])[F:63].[n:1]1[c:2]([C:11]2([NH2:14])[CH2:12][CH2:13]2)[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][n:9][c:10]12.[n:64]1([O:65][C:66]([N:67]([CH3:68])[CH3:69])=[N+:70]([CH3:71])[CH3:72])[c:73]2[n:74][cH:75][cH:76][cH:77][c:78]2[n:79][n:80]1>>[n:1]1[c:2]([C:11]2([NH:14][C:29]([c:28]3[cH:27][c:26]([F:25])[c:34]([CH3:35])[c:33](-[c:36]4[cH:37][cH:38][c:39]5[c:40]([c:41]([C:51]([NH:52][CH3:53])=[O:54])[c:42](-[c:44]6[cH:45][cH:46][c:47]([F:50])[cH:48][cH:49]6)[o:43]5)[c:55]4[F:56])[cH:32]3)=[O:30])[CH2:12][CH2:13]2)[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][n:9][c:10]12

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 58430950HCID 58430950, compoundHCID 584729003-Fluoro-5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-4-methylbenzoic acid

Product 1

HCID 533805554-fluoro-5-[3-fluoro-2-methyl-5-[[1-(1,8-naphthyridin-2-yl)cyclopropyl]carbamoyl]phenyl]-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Sources & evidence

ORD record
ord-b17835a471014dda9132a53256af69e3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…