Dichloromethane → 7-(4-Bromo-2-fluorophenyl)-4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

HRID 1212705Notes

Reaction equation

HRID 1212705 reaction equation
[Br:34][c:35]1[cH:36][c:37]([F:59])[c:38]([N:41]([C:43](=[O:44])[O:45][C:46]([CH3:47])([CH3:48])[CH3:57])[c:49]2[n:50][cH:51][n:52][c:53]([Cl:58])[c:54]2[CH2:55][CH2:56][OH:42])[cH:39][cH:40]1.[CH3:67][CH2:68][N:69]([CH2:70][CH3:71])[CH2:72][CH3:73].[Cl:74][CH2:75][Cl:76].[F:1][c:2]1[cH:3][c:4]([S:5]([CH3:6])(=[O:7])=[O:8])[cH:9][cH:10][c:11]1[N:12]1[c:13]2[n:14][cH:15][n:16][c:17]([O:18][CH:19]3[CH2:20][CH2:21][N:22]([C:23]([O:24][CH:25]([CH3:26])[CH3:27])=[O:28])[CH2:29][CH2:30]3)[c:31]2[CH2:32][CH2:33]1.[F:60][C:61]([F:62])([F:63])[C:64]([OH:65])=[O:66]>>[Br:34][c:35]1[cH:36][c:37]([F:59])[c:38]([N:41]2[c:49]3[n:50][cH:51][n:52][c:53]([Cl:58])[c:54]3[CH2:55][CH2:56]2)[cH:39][cH:40]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 236535631-Methylethyl 4-((7-(2-Fluoro-4-(methylsulfonyl)phenyl)-6,7-dihydro-5H-pyrrolo(2,3-d)pyrimidin-4-yl)oxy)-1-piperidinecarboxylateHCID 86637383tert-butyl N-(4-bromo-2-fluorophenyl)-N-[6-chloro-5-(2-hydroxyethyl)pyrimidin-4-yl]carbamate

Product 1

HCID 866373857-(4-Bromo-2-fluorophenyl)-4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-2be535c52a034e3daafb2f76b201b548
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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