Hydrochloric Acid → Tert-butyl 4-(aminocarbonyl)-4-[({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]piperidine-1-carboxylate
Reaction equation
[CH:43]([N:44]([CH2:45][CH3:46])[CH:47]([CH3:48])[CH3:49])([CH3:50])[CH3:51].[Cl:2][c:3]1[c:4]([F:24])[c:5]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:22][CH3:23])[c:17]([CH2:20][Cl:21])[cH:18][c:19]23)[cH:6][cH:7][cH:8]1.[ClH:1].[NH2:25][C:26](=[O:27])[C:28]1([NH:41][CH3:42])[CH2:29][CH2:30][N:31]([C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[CH2:32][CH2:33]1.[O:52]=[CH:53][N:54]([CH3:55])[CH3:56]>>[Cl:2][c:3]1[c:4]([F:24])[c:5]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:22][CH3:23])[c:17]([CH2:20][N:41]([C:28]4([C:26]([NH2:25])=[O:27])[CH2:29][CH2:30][N:31]([C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[CH2:32][CH2:33]4)[CH3:42])[cH:18][c:19]23)[cH:6][cH:7][cH:8]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-8d877ce52d954b3a9984f89641ddedee
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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