Hydrochloric Acid → tert-Butyl (trans-4-hydroxymethylcyclohexylmethyl)carbamate

HRID 1212829Notes

Reaction equation

HRID 1212829 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH:10]1[CH2:11][CH2:12][CH:13]([C:16](=[O:17])[OH:18])[CH2:14][CH2:15]1.[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[CH3:26][O:27][C:28]([Cl:29])=[O:30].[CH3:35][CH2:36][O:37][C:38](=[O:39])[CH3:40].[Cl:32][CH2:33][Cl:34].[ClH:31]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH:10]1[CH2:11][CH2:12][CH:13]([CH2:16][OH:17])[CH2:14][CH2:15]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 736918(1r,4r)-4-((((Tert-butoxy)carbonyl)amino)methyl)cyclohexane-1-carboxylic acid

Product 1

HCID 18397396tert-Butyl (trans-4-hydroxymethylcyclohexylmethyl)carbamate

Sources & evidence

ORD record
ord-26191b578ad14307b9a37b3bf6e19bdd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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