Citric Acid → 1-Chloro-2-methoxy-4-methylbenzene

HRID 1213819Notes

Reaction equation

HRID 1213819 reaction equation
[CH3:12][I:13].[CH3:32][CH2:33][O:34][C:35]([CH3:36])=[O:37].[Cl:3][c:4]1[c:5]([OH:11])[cH:6][c:7]([CH3:10])[cH:8][cH:9]1.[H-:1].[Na+:2].[O:27]=[CH:28][N:29]([CH3:30])[CH3:31].[OH:14][C:15]([CH2:16][C:17]([C:18](=[O:19])[OH:20])([CH2:21][C:22](=[O:23])[OH:24])[OH:25])=[O:26]>>[Cl:3][c:4]1[c:5]([O:11][CH3:15])[cH:6][c:7]([CH3:10])[cH:8][cH:9]1

Participants

8

Reactant 7

HCID 311Citric AcidHCID 923Sodium ionHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 120082-Chloro-5-methylphenolHCID 166653Hydride

Product 1

HCID 993521-Chloro-2-methoxy-4-methylbenzene

Sources & evidence

ORD record
ord-b18b7f230e414843900f6636eadf0455
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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