Tetrahydrofuran → 5-Bromo-2-[(tert-butyldimethylsilanyl)ethynyl]-3-fluoropyridine

HRID 1214062Notes

Reaction equation

[Br:10][c:11]1[n:12][cH:13][c:14]([Br:18])[cH:15][c:16]1[F:17].[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[C:8]#[CH:9].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[Cu:31][I:32]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[C:8]#[C:9][c:11]1[n:12][cH:13][c:14]([Br:18])[cH:15][c:16]1[F:17]

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 2757281(tert-Butyldimethylsilyl)acetylene

HCID 224128322,5-Dibromo-3-fluoropyridine

Product 1

HCID 690610065-Bromo-2-[(tert-butyldimethylsilanyl)ethynyl]-3-fluoropyridine

Sources & evidence

ORD record: ord-a305cc1a920b4c4e8826bfae695e104f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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