Chloride → [6-Methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

HRID 1214081Notes

Reaction equation

HRID 1214081 reaction equation
[CH2:56]1[O:57][CH2:58][CH2:59][CH2:60]1.[CH3:12][O:13][c:14]1[cH:15][c:16]2[cH:17][cH:18][c:19]([O:41][S:42]([C:43]([F:44])([F:45])[F:46])(=[O:47])=[O:48])[c:20]([C:24]([c:25]3[cH:26][cH:27][c:28]([O:31][CH2:32][CH2:33][N:34]4[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]4)[cH:29][cH:30]3)=[O:40])[c:21]2[cH:22][cH:23]1.[CH3:2][O:3][c:4]1[c:5]([CH2:6][Zn+:7])[cH:8][cH:9][cH:10][cH:11]1.[CH3:49][N:50]1[CH2:51][CH2:52][CH2:53][C:54]1=[O:55].[Cl-:1].[Cl:61][CH2:62][Cl:63].[Fe+2:100].[cH:64]1[cH:65][cH:66][c:67]([P:68]([c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)[c-:75]2[cH:76][cH:77][cH:78][cH:79]2)[cH:80][cH:81]1.[cH:82]1[cH:83][cH:84][c:85]([P:86]([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)[c-:93]2[cH:94][cH:95][cH:96][cH:97]2)[cH:98][cH:99]1>>[CH3:2][O:3][c:4]1[c:5]([CH2:6][c:19]2[cH:18][cH:17][c:16]3[cH:15][c:14]([O:13][CH3:12])[cH:23][cH:22][c:21]3[c:20]2[C:24]([c:25]2[cH:26][cH:27][c:28]([O:31][CH2:32][CH2:33][N:34]3[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]3)[cH:29][cH:30]2)=[O:40])[cH:8][cH:9][cH:10][cH:11]1

Participants

9

Reactant 8

HCID 312ChlorideHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 13387N-methyl-2-pyrrolidoneHCID 27284Ferrous cationHCID 11685250Trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)benzoyl]-naphthalen-2-yl esterHCID 178420532HCID 178420532, compound2×HCID 178489473HCID 178489473, compound

Product 1

HCID 22046618[6-Methoxy-2-(2-methoxy-benzyl)-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Sources & evidence

ORD record
ord-ca25ec2e758e4514b7a1807914256ee9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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