1,2-Dichloroethane → N1-(4-(2-(1-Ethyl-1H-imidazol-5-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-fluorophenyl)malonamide

HRID 1216365Notes

Reaction equation

HRID 1216365 reaction equation
[CH2:1]([CH3:2])[n:3]1[cH:4][n:5][cH:6][c:7]1-[c:8]1[cH:9][c:10]2[n:11][cH:12][cH:13][c:14]([O:17][c:18]3[c:19]([F:25])[cH:20][c:21]([NH2:22])[cH:23][cH:24]3)[c:15]2[s:16]1.[CH2:40]([Cl:41])[CH2:42][Cl:43].[F:26][c:27]1[c:28]([NH:33][C:34]([CH2:35][C:36](=[O:37])[OH:38])=[O:39])[cH:29][cH:30][cH:31][cH:32]1.[O:54]=[CH:55][N:56]([CH3:57])[CH3:58].[OH:44][n:45]1[c:46]2[c:47]([cH:48][cH:49][cH:50][cH:51]2)[n:52][n:53]1>>[CH2:1]([CH3:2])[n:3]1[cH:4][n:5][cH:6][c:7]1-[c:8]1[cH:9][c:10]2[n:11][cH:12][cH:13][c:14]([O:17][c:18]3[c:19]([F:25])[cH:20][c:21]([NH:22][C:36]([CH2:35][C:34]([NH:33][c:28]4[c:27]([F:26])[cH:32][cH:31][cH:30][cH:29]4)=[O:39])=[O:37])[cH:23][cH:24]3)[c:15]2[s:16]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 164811562-[(2-Fluorophenyl)carbamoyl]acetic acidHCID 587904254-(2-(1-Ethyl-1H-imidazol-5-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluoroaniline

Product 1

HCID 58790094N1-(4-(2-(1-Ethyl-1H-imidazol-5-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-fluorophenyl)malonamide

Sources & evidence

ORD record
ord-4ff54f385ab44a26849f93c29a7b276b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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