Hydrochloric Acid → 3-(2-Bromo-6-tert-butyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide
Reaction equation
[Br:18][c:19]1[n:20][c:21]([C:30]([CH3:31])([CH3:32])[CH3:33])[cH:22][cH:23][c:24]1[CH:25]=[CH:26][C:27](=[O:28])[OH:29].[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[CH3:34][N:35]1[CH2:36][CH2:37][CH2:38][C:39]1=[O:40].[ClH:17].[NH2:1][CH2:2][c:3]1[cH:4][c:5]([C:15]#[CH:16])[c:6]([NH:10][S:11](=[O:12])(=[O:13])[CH3:14])[c:7]([F:9])[cH:8]1>>[NH:1]([CH2:2][c:3]1[cH:4][c:5]([C:15]#[CH:16])[c:6]([NH:10][S:11](=[O:12])(=[O:13])[CH3:14])[c:7]([F:9])[cH:8]1)[C:27]([CH:26]=[CH:25][c:24]1[c:19]([Br:18])[n:20][c:21]([C:30]([CH3:31])([CH3:32])[CH3:33])[cH:22][cH:23]1)=[O:28]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-2485c8aee38946bea11d08bd19ecf5b5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
Loading…