Methylamine → N-methyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole-5-carboxamide

HRID 1217701Notes

Reaction equation

HRID 1217701 reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:29][NH2:30].[CH3:31][CH2:32][O:33][C:34]([CH3:35])=[O:36].[O:1]1[CH2:2][CH2:3][CH:4]([CH2:7][n:8]2[cH:9][c:10]([C:20](=[O:21])[CH:22]3[C:23]([CH3:27])([CH3:28])[C:24]3([CH3:25])[CH3:26])[c:11]3[cH:12][c:13]([C:17](=[O:18])[OH:19])[cH:14][cH:15][c:16]23)[CH2:5][CH2:6]1>>[O:1]1[CH2:2][CH2:3][CH:4]([CH2:7][n:8]2[cH:9][c:10]([C:20](=[O:21])[CH:22]3[C:23]([CH3:27])([CH3:28])[C:24]3([CH3:25])[CH3:26])[c:11]3[cH:12][c:13]([C:17](=[O:18])[NH:30][CH3:29])[cH:14][cH:15][c:16]23)[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 6329MethylamineHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 67269817HCID 67269817, compound

Product 1

HCID 67269858N-methyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole-5-carboxamide

Sources & evidence

ORD record
ord-de175ffd326841d090a2a0730c25ed1e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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