Tetrahydrofuran → 2-[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]-8-methyl-4-oxo-4H-3,1-benzoxazine-6-carbonitrile

HRID 1219278Notes

Reaction equation

HRID 1219278 reaction equation
[Br:1][c:2]1[n:3][n:4](-[c:20]2[n:21][cH:22][cH:23][cH:24][c:25]2[Cl:26])[c:5](-[c:7]2[n:8][c:9]3[c:10]([c:11](=[O:13])[o:12]2)[cH:14][c:15]([I:19])[cH:16][c:17]3[CH3:18])[cH:6]1.[CH3:35][CH2:36][O:37][C:38](=[O:39])[CH3:40].[Cu:27][C:28]#[N:29].[Cu:41][I:42].[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1>>[Br:1][c:2]1[n:3][n:4](-[c:20]2[n:21][cH:22][cH:23][cH:24][c:25]2[Cl:26])[c:5](-[c:7]2[n:8][c:9]3[c:10]([c:11](=[O:13])[o:12]2)[cH:14][c:15]([C:28]#[N:29])[cH:16][c:17]3[CH3:18])[cH:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 668578692-[5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazol-3-yl]-6-iodo-8-methyl-benzo[d][1,3]oxazin-4-oneHCID 178418546HCID 178418546, compound

Product 1

HCID 666945472-[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]-8-methyl-4-oxo-4H-3,1-benzoxazine-6-carbonitrile

Sources & evidence

ORD record
ord-817518dc5ebe490db90f1542e41f15fc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…