Hydrochloric Acid → 6-Fluoro-7-(2-fluoro-4-iodophenylamino)-8-(3-hydroxyazetidine-1-carbonyl)-2,3-dihydroindolizin-5(1H)-one

HRID 1219304Notes

Reaction equation

HRID 1219304 reaction equation
[CH3:54][N:55]1[CH2:56][CH2:57][O:58][CH2:59][CH2:60]1.[ClH:24].[F:1][c:2]1[c:3](=[O:23])[n:4]2[c:8]([c:9]([C:20](=[O:21])[OH:22])[c:10]1[NH:11][c:12]1[c:13]([F:19])[cH:14][c:15]([I:18])[cH:16][cH:17]1)[CH2:7][CH2:6][CH2:5]2.[O:61]=[CH:62][N:63]([CH3:64])[CH3:65].[OH:25][CH:26]1[CH2:27][NH:28][CH2:29]1.[P-:30]([F:31])([F:32])([F:33])([F:34])([F:35])[F:36].[n:37]1([O:38][C:39]([N:40]([CH3:41])[CH3:42])=[N+:43]([CH3:44])[CH3:45])[c:46]2[n:47][cH:48][cH:49][cH:50][c:51]2[n:52][n:53]1>>[F:1][c:2]1[c:3](=[O:23])[n:4]2[c:8]([c:9]([C:20](=[O:21])[N:28]3[CH2:27][CH:26]([OH:25])[CH2:29]3)[c:10]1[NH:11][c:12]1[c:13]([F:19])[cH:14][c:15]([I:18])[cH:16][cH:17]1)[CH2:7][CH2:6][CH2:5]2

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 79724-MethylmorpholineHCID 9886HexafluorophosphateHCID 15142903-HydroxyazetidineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 252657696-Fluoro-7-(2-fluoro-4-iodophenylamino)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylic acid

Product 1

HCID 426062066-Fluoro-7-(2-fluoro-4-iodophenylamino)-8-(3-hydroxyazetidine-1-carbonyl)-2,3-dihydroindolizin-5(1H)-one

Sources & evidence

ORD record
ord-5d16350092264be0866a356813836ec0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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