Triethylamine → 3-(3-Bromo-4-fluorophenylethynyl)-5-chloropyridine

HRID 121992Notes

Reaction equation

HRID 121992 reaction equation
[Br:10][c:11]1[c:12]([F:18])[cH:13][cH:14][c:15]([I:17])[cH:16]1.[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[Cl:1][c:2]1[cH:3][n:4][cH:5][c:6]([C:8]#[CH:9])[cH:7]1.[Cu:67][I:68].[Pd:26]([Cl:27])[Cl:28].[c:29]1([P:30]([c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[cH:43][cH:44][cH:45][cH:46][cH:47]1.[c:48]1([P:49]([c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[cH:62][cH:63][cH:64][cH:65][cH:66]1>>[Cl:1][c:2]1[cH:3][n:4][cH:5][c:6]([C:8]#[C:9][c:15]2[cH:14][cH:13][c:12]([F:18])[c:11]([Br:10])[cH:16]2)[cH:7]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 27569802-Bromo-1-fluoro-4-iodobenzeneHCID 235008873-Chloro-5-ethynylpyridine

Product 1

HCID 670474403-(3-Bromo-4-fluorophenylethynyl)-5-chloropyridine

Sources & evidence

ORD record
ord-815167fd96014e4697c27a1c5cbed77e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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