Hydrochloric Acid → 4-(3-Chloro-4-fluorophenyl)-N-(1-(2-chloropyridin-4-yl)piperidin-4-yl)-6-methylbenzo[d]thiazol-2-amine

HRID 1222313Notes

Reaction equation

HRID 1222313 reaction equation
[Br:1][c:2]1[s:3][c:4]2[c:5]([n:6]1)[c:7](-[c:12]1[cH:13][c:14]([Cl:19])[c:15]([F:18])[cH:16][cH:17]1)[cH:8][c:9]([CH3:11])[cH:10]2.[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[CH3:43][C:44]([N:45]([CH3:46])[CH3:47])=[O:48].[Cl:22][c:23]1[n:24][cH:25][cH:26][c:27]([N:29]2[CH2:30][CH2:31][CH:32]([NH2:35])[CH2:33][CH2:34]2)[cH:28]1.[Cl:49][CH2:50][Cl:51].[ClH:20].[ClH:21]>>[c:2]1([NH:35][CH:32]2[CH2:31][CH2:30][N:29]([c:27]3[cH:26][cH:25][n:24][c:23]([Cl:22])[cH:28]3)[CH2:34][CH2:33]2)[s:3][c:4]2[c:5]([n:6]1)[c:7](-[c:12]1[cH:13][c:14]([Cl:19])[c:15]([F:18])[cH:16][cH:17]1)[cH:8][c:9]([CH3:11])[cH:10]2

Participants

7

Reactant 6

HCID 313Hydrochloric Acid2×HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31374DimethylacetamideHCID 673424052-Bromo-4-(3-chloro-4-fluorophenyl)-6-methylbenzo[d]thiazoleHCID 866567101-(2-Chloro-4-pyridinyl)piperidin-4-amine

Product 1

HCID 866567134-(3-Chloro-4-fluorophenyl)-N-(1-(2-chloropyridin-4-yl)piperidin-4-yl)-6-methylbenzo[d]thiazol-2-amine

Sources & evidence

ORD record
ord-73081b48a3044bcdab2322aac679e7eb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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