Acetate → 5-Methoxy-3-(2-methoxycarbonyl-vinyl)-indazole-1-carboxylic acid tert-butyl ester

HRID 1223074Notes

Reaction equation

HRID 1223074 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[n:9][c:10]([I:19])[c:11]2[cH:12][c:13]([O:17][CH3:18])[cH:14][cH:15][c:16]12.[C:27]([CH:28]=[CH2:29])(=[O:30])[O:31][CH3:32].[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[CH2:25][CH3:26].[O-:59][C:60]([CH3:61])=[O:62].[O-:63][C:64]([CH3:65])=[O:66].[O:52]1[CH2:53][CH2:54][O:55][CH2:56][CH2:57]1.[Pd+2:58].[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[cH:47][cH:48][cH:49][cH:50][cH:51]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[n:9][c:10]([CH:29]=[CH:28][C:27](=[O:30])[O:31][CH3:32])[c:11]2[cH:12][c:13]([O:17][CH3:18])[cH:14][cH:15][c:16]12

Participants

8

Reactant 7

HCID 175Acetate2×HCID 7294Methyl AcrylateHCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 312751,4-DioxaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 20785164HCID 20785164, compound

Product 1

HCID 696182895-Methoxy-3-(2-methoxycarbonyl-vinyl)-indazole-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-e553eedad7fe4a9b83a6cbd407a9e2bb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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