Water → 2-(4-(1,4-Dimethylpiperidin-4-yl)phenylamino)-5-fluoro-6-(3-phenyl-1-oxa-2,7-diazaspiro[4.5]dec-2-en-7-yl)nicotinamide
Reaction equation
[CH3:52][N:53]1[CH2:54][CH2:55][CH2:56][C:57]1=[O:58].[CH:43]([N:44]([CH2:45][CH3:46])[CH:47]([CH3:48])[CH3:49])([CH3:50])[CH3:51].[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[cH:14][cH:15][c:16]([C:19]3([CH3:26])[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]3)[cH:17][cH:18]2)[c:5]([C:6](=[O:7])[NH2:8])[cH:9][c:10]1[F:11].[OH2:59].[c:27]1([C:33]2=[N:34][O:35][C:36]3([CH2:37]2)[CH2:38][NH:39][CH2:40][CH2:41][CH2:42]3)[cH:28][cH:29][cH:30][cH:31][cH:32]1>>[c:2]1([N:39]2[CH2:38][C:36]3([O:35][N:34]=[C:33]([c:27]4[cH:28][cH:29][cH:30][cH:31][cH:32]4)[CH2:37]3)[CH2:42][CH2:41][CH2:40]2)[n:3][c:4]([NH:12][c:13]2[cH:14][cH:15][c:16]([C:19]3([CH3:26])[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]3)[cH:17][cH:18]2)[c:5]([C:6](=[O:7])[NH2:8])[cH:9][c:10]1[F:11]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-d968966545b349ee8bb1c28b6b7b502a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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