Tetrahydrofuran → Ethyl 4-oxooxane-3-carboxylate

HRID 1226569Notes

Reaction equation

HRID 1226569 reaction equation
[C:27](#[N:28])[C:29](=[O:30])[O:31][CH2:32][CH3:33].[CH3:16][N:17]([CH3:18])[P:19](=[O:20])([N:21]([CH3:22])[CH3:23])[N:24]([CH3:25])[CH3:26].[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Li+:8].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1.[O:9]1[CH2:10][CH2:11][C:12](=[O:15])[CH2:13][CH2:14]1>>[O:9]1[CH2:10][CH:11]([C:29](=[O:30])[O:31][CH2:32][CH3:33])[C:12](=[O:15])[CH2:13][CH2:14]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 12679HexamethylphosphoramideHCID 28486Lithium ionHCID 69336Ethyl cyanoformateHCID 121599Tetrahydro-4H-pyran-4-oneHCID 5062348Diisopropylamide

Product 1

HCID 19783095Ethyl 4-oxooxane-3-carboxylate

Sources & evidence

ORD record
ord-61a878b9a10e4c548c8051f069e43c2c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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