Hydrochloric Acid → N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine

HRID 1228261Notes

Reaction equation

HRID 1228261 reaction equation
[CH3:25][N:26]1[C:27](=[O:28])[CH2:29][CH2:30][CH2:31]1.[Cl:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([c:8]1[NH:9][c:10]1[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([F:21])[cH:17][c:18]([F:20])[c:19]13)[O:22][CH2:23][O:24]2.[ClH:1].[OH2:39].[OH:32][CH:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1>>[Cl:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([c:8]1[NH:9][c:10]1[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([F:21])[cH:17][c:18]([O:32][CH:33]4[CH2:34][CH2:35][O:36][CH2:37][CH2:38]4)[c:19]13)[O:22][CH2:23][O:24]2

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 13387N-methyl-2-pyrrolidoneHCID 74956Tetrahydro-4H-pyran-4-olHCID 11695717N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-5,7-difluoroquinazolin-4-amine

Product 1

HCID 11654626N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine

Sources & evidence

ORD record
ord-4ff500b9054643edbcb7346c26560bde
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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