1,1-Dichloroethane → N-Desmethyl sorafenib
Reaction equation
[C:13](=[O:14])([n:15]1[cH:16][cH:17][n:18][cH:19]1)[n:20]1[cH:21][cH:22][n:23][cH:24]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:51][CH2:52][O:53][C:54]([CH3:55])=[O:56].[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH2:6])[cH:7][c:8]1[C:9]([F:10])([F:11])[F:12].[Cl:47][CH:48]([Cl:49])[CH3:50].[NH2:25][c:26]1[cH:27][cH:28][c:29]([O:30][c:31]2[cH:32][c:33]([C:37](=[O:38])[NH2:39])[n:34][cH:35][cH:36]2)[cH:40][cH:41]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH:6][C:13](=[O:14])[NH:25][c:26]2[cH:27][cH:28][c:29]([O:30][c:31]3[cH:32][c:33]([C:37](=[O:38])[NH2:39])[n:34][cH:35][cH:36]3)[cH:40][cH:41]2)[cH:7][c:8]1[C:9]([F:10])([F:11])[F:12]Participants
7
Sources & evidence
- ORD record
- ord-f016971711b5431d9a0d67a566a42af8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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