Dimethylformamide → 6-chloro-N-[3-[4-[4-(2-methoxyethoxy)-N-[(4-methyl-3-pyridinyl)methyl]anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide

HRID 1228384Notes

Reaction equation

HRID 1228384 reaction equation
[CH3:32][c:33]1[c:34]([C:35](=[O:36])[OH:37])[c:38]([CH3:43])[cH:39][c:40]([Cl:42])[n:41]1.[CH3:63][CH2:64][N:65]=[C:66]=[N:67][CH2:68][CH2:69][CH2:70][N:71]([CH3:72])[CH3:73].[CH:44]([N:45]([CH2:46][CH3:47])[CH:48]([CH3:49])[CH3:50])([CH3:51])[CH3:52].[NH2:1][CH2:2][CH2:3][CH:4]([CH3:5])[N:6]1[CH2:7][CH2:8][CH:9]([N:12]([CH2:13][c:14]2[cH:15][n:16][cH:17][cH:18][c:19]2[CH3:20])[c:21]2[cH:22][cH:23][c:24]([O:27][CH2:28][CH2:29][O:30][CH3:31])[cH:25][cH:26]2)[CH2:10][CH2:11]1.[O:74]=[CH:75][N:76]([CH3:77])[CH3:78].[OH:53][n:54]1[c:55]2[c:56]([cH:57][cH:58][cH:59][cH:60]2)[n:61][n:62]1>>[NH:1]([CH2:2][CH2:3][CH:4]([CH3:5])[N:6]1[CH2:7][CH2:8][CH:9]([N:12]([CH2:13][c:14]2[cH:15][n:16][cH:17][cH:18][c:19]2[CH3:20])[c:21]2[cH:22][cH:23][c:24]([O:27][CH2:28][CH2:29][O:30][CH3:31])[cH:25][cH:26]2)[CH2:10][CH2:11]1)[C:35]([c:34]1[c:33]([CH3:32])[n:41][c:40]([Cl:42])[cH:39][c:38]1[CH3:43])=[O:36]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 34465636-Chloro-2,4-dimethylnicotinic acidHCID 689697291-(4-aminobutan-2-yl)-N-[4-(2-methoxyethoxy)phenyl]-N-[(4-methyl-3-pyridinyl)methyl]piperidin-4-amine

Product 1

HCID 750377516-chloro-N-[3-[4-[4-(2-methoxyethoxy)-N-[(4-methyl-3-pyridinyl)methyl]anilino]piperidin-1-yl]butyl]-2,4-dimethylpyridine-3-carboxamide

Sources & evidence

ORD record
ord-54fbad5e05914a9f9f49ca413b7e1d4b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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