Water → 5-Hydroxy-5-(2,2,2-trifluoro-ethoxymethyl)-2-(4-trifluoromethoxy-phenyl)-hexahydro-cyclopenta[c]pyrrol-1-one

HRID 1228832Notes

Reaction equation

HRID 1228832 reaction equation
[F:2][C:3]([CH2:4][OH:5])([F:6])[F:7].[F:8][C:9]([O:10][c:11]1[cH:12][cH:13][c:14]([N:17]2[C:18](=[O:27])[CH:19]3[CH:20]([CH2:21]2)[CH2:22][C:23]2([CH2:24]3)[O:25][CH2:26]2)[cH:15][cH:16]1)([F:28])[F:29].[Na:1].[OH2:30]>>[F:2][C:3]([CH2:4][O:5][CH2:26][C:23]1([OH:25])[CH2:22][CH:20]2[CH:19]([C:18](=[O:27])[N:17]([c:14]3[cH:13][cH:12][c:11]([O:10][C:9]([F:8])([F:28])[F:29])[cH:16][cH:15]3)[CH2:21]2)[CH2:24]1)([F:6])[F:7]

Participants

5

Reactant 4

HCID 962WaterHCID 64092,2,2-TrifluoroethanolHCID 5360545SodiumHCID 86673919rac-(3aR,5S,6aS)-2-[4-(trifluoromethoxy)phenyl]hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-oxiran]-1-one

Product 1

HCID 780785935-Hydroxy-5-(2,2,2-trifluoro-ethoxymethyl)-2-(4-trifluoromethoxy-phenyl)-hexahydro-cyclopenta[c]pyrrol-1-one

Sources & evidence

ORD record
ord-3b093375553d423880abcc43d22b7bcd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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